The first thing you, or anyone, should put into consoderation when using Facebook whether you want your account to be personal or professional. Alternatively, you aught to feel free to set up more than one account inorder to keep the people and the messages separate.
Here are some of the DOs and DON'Ts:
DO Be reasonably selective. You don't want to add your boss to your social account, do you?
DON'T You don't have to confirm all the requests. Feel free to abandon the burdenning ones and not 'poke' back. The good news is that it is not considered rude anymore.
DO Consider whether your profile is private or public. Private is just for your friends while public for everyone.
DON'T Don't use offensive profile photos, or put up an album with tastless or ponographic images. You never know who is checking out your site don't risk upsetting anyone. Your profile is a reflection of your personality.
DO Use the "report as spam" button to avoid junk mail. This is especially when you find an application is automatically sending you spam notifications.
DON'T Don't send multi-recipient messages. What you don't know is that Facebook defaults the option "Reply to all".
Finally, about the wall-to-wall thing. If your conversation gets personal, please go to inbox. Not everyone is worth seeing you naked.
